Na+/Ca2+ Exchanger

Related Products

Na⁺/Ca²⁺ exchanger (sodium-calcium exchanger , NCX) is an antiporter membrane protein that removes calcium from cells. It uses the energy that is stored in the electrochemical gradient of sodium (Na⁺) by allowing Na⁺ to flow down its gradient across the plasma membrane in exchange for the countertransport of calcium ions (Ca²⁺). Na⁺/Ca²⁺ exchanger removes a single calcium ion in exchange for the import of three sodium ions. Na⁺/Ca²⁺ exchanger exists in many different cell types and animal species. Na⁺/Ca²⁺ exchanger is considered one of the most important cellular mechanisms for removing Ca²⁺. The Na⁺/Ca²⁺ exchanger does not bind very tightly to Ca²⁺ (has a low affinity), but it can transport the ions rapidly (has a high capacity), transporting up to five thousand Ca²⁺ ions per second. The Na⁺/Ca²⁺ exchanger also likely plays an important role in regaining the cell's normal calcium concentrations after an excitotoxic insult.

Na+/Ca2+ Exchanger Related Products (31):

By Effects:	Inhibitors (24) Agonists (2) Activators (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-100298

Caldaret	Inhibitor	98.35%
Caldaret is an intracellular Ca²⁺ handling modulator that acts through reverse mode Na⁺/Ca²⁺ exchanger inhibition.

HY-P10811

Na+-Ca2+ Exchanger	Inhibitor
Na⁺-Ca²⁺ Exchanger inhibitory peptide (XIP) is a Na⁺-Ca²⁺ exchanger inhibitor with a K_i of 200 nM. Na⁺-Ca²⁺ Exchanger inhibitory peptide inhibits the Na⁺-dependent Ca²⁺ uptake and the Na⁺-dependent Ca²⁺ efflux of sarcolemmal vesicles in a noncompetitive manner.

HY-138947

KB-R7943	Inhibitor
KB-R7943 (compound 1) is an inhibitor of sodium-calcium exchanger with an IC₅₀ value of 5.1 μM. KB-R7943 can be used as a tool in heart and renal failure models.

HY-B1546

Benzamil	Inhibitor
Benzamil (Benzylamiloride), an Amiloride analogue, is a Na⁺/Ca²⁺ exchanger (NCX) inhibitor (IC₅₀~100 nM). Benzamil also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil inhibits TRPP3-mediated Ca²⁺-activated currents, with an IC₅₀ of 1.1 μM.

HY-164684

Dichlorobenzamil	Inhibitor
Dichlorobenzamil (3',4'-Dichlorobenzamil; L-594881) is an effective Na/Ca exchange inhibitor. Dichlorobenzamil significantly inhibits ⁴⁵Ca uptake mediated by reverse Na/Ca exchange in pancreatic islet cells (IC₅₀ = 18 μM). Dichlorobenzamil can also block K⁺ channels and voltage-sensitive Ca²⁺ channels.

HY-100298R

Caldaret (Standard)	Inhibitor
Caldaret (Standard) is the analytical standard of Caldaret (HY-100298). This product is intended for research and analytical applications. Caldaret is an intracellular Ca2+ handling modulator that acts through reverse mode Na+/Ca2+ exchanger inhibition.

HY-107659R

YM-244769 hydrochloride (Standard)	Inhibitor
YM-244769 hydrochloride (Standard) is the analytical standard of YM-244769 (hydrochloride) (HY-107659). This product is intended for research and analytical applications. YM-244769 hydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC₅₀s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice.

HY-107658R

SN 6 (Standard)	Inhibitor
SN 6 (Standard) is the analytical standard of SN 6 (HY-107658). This product is intended for research and analytical applications. SN 6 is a selective Na+/Ca2+ exchanger (NCX) inhibitor, and inhibits 45Ca2+ uptake by NCX1, NCX2, and NCX3, with IC₅₀s of 2.9, 16, and 8.6 μM, respectively.

HY-B1193S

Terfenadine-d₃
Terfenadine-d₃ ((±)-Terfenadine-d₃) is the deuterium labeled Terfenadine. Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC₅₀ of 204 nM. Terfenadine, an H1 histamine receptor antagonist, acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis, simultaneously activates Caspase-4, -2, -9[2].

HY-B1546AR

Benzamil hydrochloride (Standard)	Inhibitor
Benzamil (hydrochloride) (Standard) is the analytical standard of Benzamil (hydrochloride). This product is intended for research and analytical applications. Benzamil hydrochloride (Benzylamiloride hydrochloride), an Amiloride analogue, is a Na+/Ca2+ exchanger (NCX) inhibitor (IC50~100 nM). Benzamil hydrochloride also is a non-selective Deg/epithelial sodium channels (ENaC) blocker, and can potentiate myogenic vasoconstriction. Benzamil hydrochloride inhibits TRPP3-mediated Ca2+-activated currents, with an IC50 of 1.1 μM.

HY-19062

SM-6586	Inhibitor
SM-6586 is a calcium channel antagonist and inhibitor of Na⁺/H⁺ and Na⁺/Ca²⁺ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.

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